A group of Japanese scientists in 1994 discovered perrotetinene in liverworts, but the new study is the strongest evidence yet that the compound is a psychoactive cannabinoid. Previously, cannabis was the only plant known to produce such cannabinoids....
After mapping perrotetinene’s molecular structure, the researchers created a synthetic version and tested it on mice. The team tracked the animals’ pain response, body temperature and movement — measures of the compound’s psychoactivity. The results suggested that perrotetinene may be slightly less psychoactive than THC, says study coauthor Jürg Gertsch, a biochemist at the University of Bern in Switzerland. The liverwort compound may also have fewer negative side effects such as memory loss and loss of coordination, he says.
"Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high" (Science Advances)
illustration: "Hepaticae" from Ernst Haeckel's Kunstformen der Natur, 1904
